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Hydrochlorothiazide (brand names: Apo-Hydro / Aquazide H / Dichlotride / Hydrodiuril / Hydarazide / Microzide / Oretic / Moduretic / Inderide / Dyazide / Aldactazide / Aldoril), sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug (water pill) that acts by inhibiting the kidney's ability to retain water. This reduces the volume of the blood, decreasing blood return to the heart and thus cardiac output and, by other mechanisms, is believed to lower peripheral vascular resistance.


What should I tell my health care provider before I take Microzide?

They need to know if you have any of these conditions:

•   diabetes
•   gout
•   immune system problems, like lupus
•   kidney disease or kidney stones
•   liver disease
•   pancreatitis
•   small amount of urine or difficulty passing urine
•   an unusual or allergic reaction to hydrochlorothiazide, sulfa drugs, other medicines, foods, dyes, or preservatives
•   pregnant or trying to get pregnant
•   breast-feeding


How should I use Microzide?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Remember that you will need to pass urine frequently after taking this medicine. Do not take your doses at a time of day that will cause you problems. Do not stop taking your medicine unless your doctor tells you to.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with Microzide?

•   cholestyramine
•   colestipol
•   digoxin
•   dofetilide
•   lithium
•   medicines for blood pressure
•   medicines for diabetes
•   medicines that relax muscles for surgery
•   other diuretics
•   steroid medicines like prednisone or cortisone

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using Microzide?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.

You may need to be on a special diet while taking this medicine. Ask your doctor.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

•   allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
•   chest pain
•   fast or irregular heartbeat
•   feeling faint or lightheaded, falls
•   gout attack
•   muscle pain or cramps
•   pain or difficulty when passing urine
•   pain, tingling, numbness in the hands or feet
•   redness, blistering, peeling or loosening of the skin, including inside the mouth
•   unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

•   blurred vision
•   dry mouth
•   headache
•   stomach upset

This list may not describe all possible side effects.

Where should I keep Microzide?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Do not freeze. Protect from light and moisture. Keep container closed tightly. Throw away any unused medicine after the expiration date.

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